ABOUT US

Seven Star Pharmaceutical Services is a technology-driven Contract Research Organization (CRO) that focuses on solving the drug development problems through solid state chemistry/materials science and engineering principles.  We work with our clients to ensure comprehensive solutions for their needs in solid-state chemistry research, crystallization process development, and preformulation studies.  Based on the molecular level understanding of materials, we guide clients in the discovery and selection of the optimal solid form for drug development using all aspects of pre-formulation studies, including API process development, regulatory support and intellectual property protection.  We are flexible and deliver timely, practical, and cost-effective solutions.  Our programs include salt screening, co-crystal screening, crystallization screening, polymorph screening, amorphization, scale-up crystallization, physico-chemical properties testing, particle engineering and structure elucidation of solid forms by single crystal X-ray diffraction.

 

STRUCTURE DETERMINATION FROM SINGLE CRYSTAL XRD

Scientists routinely use techniques such as NMR (including COSY, NOESY, HETCOR ….), IR, Raman and UV spectroscopy, mass spectrometry, and elemental analysis for the identification and characterization of compounds. After a tedious analysis and interpretation of the experimental data, obtained from these techniques, may yield important information concerning the composition and structure of a compound. However, such information is often incomplete, fragmentary and ambiguous.


In contrast, single crystal XRD one of the most powerful techniques to determine with certainty three-dimensional arrangement of atoms/ions in crystalline materials.  It provides lots of information such as the composition and structure of a compound, atomic connectivity, confirmation (including the absolute stereochemistry), accurate bond lengths and angles, density, packing, hydrogen bonding networks, presence of channels, and solvent location.

Figure 1.  X-ray diffractometer with Cu source and an extremely sensitive Photon II CPAD detector.


At Seven Star, we have Bruker D8 Quest single crystal X-ray diffractometer instrument with Cu source and an extremely sensitive Photon II CPAD detector (Figure 1).  It is also equipped with an Oxford Cryosystems Cryostream device for low temperature data collection capability down to about 90 K.

For all the solid form screening projects, we always strive to provide single crystal structure for every crystalline form we discover most importantly without an extra charge. 

Our flat rate for the single crystal structure determination project including full report is $1000/structure.


What happens when we can’t grow suitable quality crystals?

We do understand the challenges in growing suitable quality crystals and sometimes it could be really difficult.  In those situations we only charge $500 for that structure determination project. 

ANALYTICAL TESTING SERVICES

Seven Star Pharmaceutical Services also offer routine testing on pharmaceutical solids at highly affordable pricing without compromising on its quality.  It is our commitment and vision to make the drug development costs affordable.

MEET THE TEAM

Seven Star Pharmaceutical Services team has more than 10 years of experience in solid form screening & selection, supporting pre-formulation and formulation development programs.  Providing molecular level of understanding of the materials is the specialty of this team.

 
CONTACT US

Seven Star Pharmaceutical Services 

501 Silverside Road, Suite #71 

Wilmington, Delaware 19809

email: info@sevenstarpharm.com

Phone: 302-483-7318